7-cyano-7-deazaguanine synthase

7-cyano-7-deazaguanine synthase (EC 6.3.4.20, preQ0 synthase, 7-cyano-7-carbaguanine synthase, queC (gene)) is an enzyme with systematic name 7-carboxy-7-carbaguanine:ammonia ligase (ADP-forming).^[1]^[2] This enzyme catalyses the following chemical reaction

7-carboxy-7-carbaguanine + NH₃ + ATP

\rightleftharpoons

7-cyano-7-carbaguanine + ADP + phosphate + H₂O

This enzyme binds Zn²⁺.

References

↑ McCarty, R.M.; Somogyi, A.; Lin, G.; Jacobsen, N.E.; Bandarian, V. (2009). "The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of preQ₀ from guanosine 5′-triphosphate in four steps". Biochemistry. 48: 3847–3852. doi:10.1021/bi900400e. PMID 19354300.
↑ Cicmil, N.; Huang, R.H. (2008). "Crystal structure of QueC from Bacillus subtilis: an enzyme involved in preQ₁ biosynthesis". Proteins. 72: 1084–1088. doi:10.1002/prot.22098. PMID 18491386.

External links

7-cyano-7-deazaguanine synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Enzymes: CO CS and CN ligases (EC 6.1-6.3)

6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine

6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase

6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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