7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase

7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (EC 2.5.1.77, FO synthase) is an enzyme with systematic name 5-amino-6-(D-ribitylamino)uracil:4-hydroxyphenylpyruvate, 4-methylphenol transferase.^[1]^[2] This enzyme catalyses the following chemical reaction

5-amino-6-(D-ribitylamino)uracil + 3-(4-hydroxyphenyl)pyruvate + 2 S-adenosyl-L-methionine + H₂O

\rightleftharpoons

7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 L-methionine + 2 5'-deoxyadenosine + oxalate + NH₃

This enzyme binds a 4Fe-4S cluster.

References

↑ Graham, D.E.; Xu, H.; White, R.H. (2003). "Identification of the 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase required for coenzyme F₄₂₀ biosynthesis". Arch. Microbiol. 180 (6): 455–464. doi:10.1007/s00203-003-0614-8. PMID 14593448.
↑ Choi, K.P.; Kendrick, N.; Daniels, L. (2002). "Demonstration that fbiC is required by Mycobacterium bovis BCG for coenzyme F₄₂₀ and FO biosynthesis". J. Bacteriol. 184 (9): 2420–2428. doi:10.1128/JB.184.9.2420-2428.2002. PMC 134996. PMID 11948155.

External links

7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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