6-Hydroxynicotinate 3-monooxygenase
| 6-Hydroxynicotinate 3-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.114 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
6-Hydroxynicotinate 3-monooxygenase (EC 1.14.13.114, NicC, 6HNA monooxygenase, HNA-3-monooxygenase) is an enzyme with systematic name 6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating).[1][2] This enzyme catalyses the following chemical reaction
- 6-hydroxynicotinate + NADH + H+ + O2 2,5-dihydroxypyridine + NAD+ + H2O + CO2
6-Hydroxynicotinate 3-monooxygenase a flavoprotein (FAD).
References
- ↑ Nakano, H.; Wieser, M.; Hurh, B.; Kawai, T.; Yoshida, T.; Yamane, T.; Nagasawa, T. (1999). "Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5". Eur. J. Biochem. 260 (1): 120–126. doi:10.1046/j.1432-1327.1999.00124.x. PMID 10091591.
- ↑ Jimenez, J.I.; Canales, A.; Jimenez-Barbero, J.; Ginalski, K.; Rychlewski, L.; Garcia, J.L.; Diaz, E. (2008). "Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440". Proc. Natl. Acad. Sci. USA. 105 (32): 11329–11334. doi:10.1073/pnas.0802273105. PMC 2516282
. PMID 18678916.
External links
- 6-hydroxynicotinate 3-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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