23S rRNA (cytidine1920-2'-O)-methyltransferase

23S rRNA (cytidine1920-2'-O)-methyltransferase
Identifiers
EC number 2.1.1.226
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

23S rRNA (cytidine1920-2'-O)-methyltransferase (EC 2.1.1.226, TlyA) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (cytidine1920-2'-O)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine1920 in 23S rRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA

This is a bifunctional enzyme from Mycobacterium tuberculosis.

References

  1. Johansen, S.K.; Maus, C.E.; Plikaytis, B.B.; Douthwaite, S. (2006). "Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2-O-methylations in 16S and 23S rRNAs". Mol. Cell. 23: 173–182. doi:10.1016/j.molcel.2006.05.044. PMID 16857584.
  2. Maus, C.E.; Plikaytis, B.B.; Shinnick, T.M. (2005). "Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis". Antimicrob. Agents Chemother. 49: 571–577. doi:10.1128/AAC.49.2.571-577.2005. PMID 15673735.

External links

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