23S rRNA (adenosine1067-2'-O)-methyltransferase

23S rRNA (adenosine1067-2'-O)-methyltransferase
Identifiers
EC number 2.1.1.230
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

23S rRNA (adenosine1067-2'-O)-methyltransferase (EC 2.1.1.230, 23S rRNA A1067 2'-methyltransferase, thiostrepton-resistance methylase, nosiheptide-resistance methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenosine1067-2'-O)-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenosine1067 in 23S rRNA S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA

The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus.

References

  1. Bechthold, A.; Floss, H.G. (1994). "Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA". Eur. J. Biochem. 224: 431–437. doi:10.1111/j.1432-1033.1994.00431.x. PMID 7925357.
  2. Thompson, J.; Schmidt, F.; Cundliffe, E. (1982). "Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton". J. Biol. Chem. 257: 7915–7917. PMID 6806287.
  3. Thompson, J.; Cundliffe, E. (1981). "Purification and properties of an RNA methylase produced by Streptomyces azureus and involved in resistance to thiostrepton". J. Gen. Microbiol. 124: 291–297. doi:10.1099/00221287-124-2-291.
  4. Yang, H.; Wang, Z.; Shen, Y.; Wang, P.; Jia, X.; Zhao, L.; Zhou, P.; Gong, R.; Li, Z.; Yang, Y.; Chen, D.; Murchie, A.I.; Xu, Y. (2010). "Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus". Biochemistry. 49: 6440–6450. doi:10.1021/bi1005915. PMID 20550164.

External links

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