2-Deoxystreptamine glucosyltransferase

2-deoxystreptamine glucosyltransferase
Identifiers
EC number 2.4.1.284
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2-deoxystreptamine glucosyltransferase (EC 2.4.1.284, kanF (gene)) is an enzyme with systematic name UDP-alpha-D-glucose:2-deoxystreptamine 6-alpha-D-glucosyltransferase.[1] This enzyme catalyses the following chemical reaction

UDP-alpha-D-glucose + 2-deoxystreptamine UDP + 2'-deamino-2'-hydroxyparomamine

This enzyme is involved in the biosynthesis of kanamycin B and kanamycin C.

References

  1. Park, J.W.; Park, S.R.; Nepal, K.K.; Han, A.R.; Ban, Y.H.; Yoo, Y.J.; Kim, E.J.; Kim, E.M.; Kim, D.; Sohng, J.K.; Yoon, Y.J. (2011). "Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation". Nat. Chem. Biol. 7 (11): 843–852. doi:10.1038/nchembio.671. PMID 21983602.

External links

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