2,5-diketocamphane 1,2-monooxygenase
| 2,5-diketocamphane 1,2-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.162 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
2,5-diketocamphane 1,2-monooxygenase (EC 1.14.13.162, 2,5-diketocamphane lactonizing enzyme, ketolactonase I, 2,5-diketocamphane 1,2-monooxygenase oxygenating component, 2,5-DKCMO, camP (gene), camphor 1,2-monooxygenase, camphor ketolactonase I) is an enzyme with systematic name (+)-bornane-2,5-dione,NADH:oxygen oxidoreductase (1,2-lactonizing).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- (+)-bornane-2,5-dione + O2 + NADH + H+ (+)-5-oxo-1,2-campholide + NAD+ + H2O
2,5-diketocamphane 1,2-monooxygenase is a flavoprotein (FMN) which requires Fe2+.
References
- ↑ Conrad, H.E.; DuBus, R.; Namtvedt, M.J.; Gunsalus, I.C. (1965). "Mixed function oxidation. II. Separation and properties of the enzymes catalyzing camphor lactonizaton". J. Biol. Chem. 240: 495–503. PMID 14253460.
- ↑ Yu, C.A.; Gunsalus, I.C. (1969). "Monoxygenases. VII. Camphor ketolactonase I and the role of three protein components". J. Biol. Chem. 244 (22): 6149–6152. PMID 4310834.
- ↑ Taylor, D.G.; Trudgill, P.W. (1986). "Camphor revisited: studies of 2,5-diketocamphane 1,2-monooxygenase from Pseudomonas putida ATCC 17453". J. Bacteriol. 165 (2): 489–497. PMC 214445
. PMID 3944058. - ↑ Selifonov, S.A. (1992). "Microbial oxidation of adamantanone by Pseudomonas putida carrying the camphor catabolic plasmid". Biochem. Biophys. Res. Commun. 186 (3): 1429–1436. doi:10.1016/s0006-291x(05)81566-9. PMID 1510672.
- ↑ Jones, K.H.; Smith, R.T.; Trudgill, P.W. (1993). "Diketocamphane enantiomer-specific ’Baeyer-Villiger’ monooxygenases from camphor-grown Pseudomonas putida ATCC 17453". J. Gen. Microbiol. 139 (4): 797–805. doi:10.1099/00221287-139-4-797. PMID 8515237.
- ↑ Kadow, M.; Sass, S.; Schmidt, M.; Bornscheuer, U.T. (2011). "Recombinant expression and purification of the 2,5-diketocamphane 1,2-monooxygenase from the camphor metabolizing Pseudomonas putida strain NCIMB 10007". AMB Express. 1 (1): #13–13. doi:10.1186/2191-0855-1-13. PMC 3222318. PMID 21906366.
External links
- 2,5-diketocamphane 1,2-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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