18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase

18S rRNA (adenine¹⁷⁷⁹-N⁶/adenine¹⁷⁸⁰-N⁶)-dimethyltransferase (EC 2.1.1.183, 18S rRNA dimethylase Dim1p, Dim1p, ScDim1, m2(6)A dimethylase, KIDIM1) is an enzyme with systematic name S-adenosyl-L-methionine:18S rRNA (adenine¹⁷⁷⁹-N⁶/adenine¹⁷⁸⁰-N6)-dimethyltransferase.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

4 S-adenosyl-L-methionine + adenine¹⁷⁷⁹/adenine¹⁷⁸⁰ in 18S rRNA

\rightleftharpoons

4 S-adenosyl-L-homocysteine + N⁶-dimethyladenine¹⁷⁷⁹/N⁶-dimethyladenine¹⁷⁸⁰ in 18S rRNA

DIM1 is involved in pre-rRNA processing.

References

↑ Lafontaine, D.; Vandenhaute, J.; Tollervey, D. (1995). "The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast". Genes Dev. 9: 2470–2481. doi:10.1101/gad.9.20.2470. PMID 7590228.
↑ Lafontaine, D.L.; Preiss, T.; Tollervey, D. (1998). "Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis". Mol. Cell. Biol. 18: 2360–2370. doi:10.1128/mcb.18.4.2360. PMID 9528805.
↑ Pulicherla, N.; Pogorzala, L.A.; Xu, Z.; O'Farrell, H.C.; Musayev, F.N.; Scarsdale, J.N.; Sia, E.A.; Culver, G.M.; Rife, J.P. (2009). "Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases". J. Mol. Biol. 391: 884–893. doi:10.1016/j.jmb.2009.06.015. PMID 19520088.
↑ Lafontaine, D.; Delcour, J.; Glasser, A.L.; Desgres, J.; Vandenhaute, J. (1994). "The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3′-terminal loop of 18 S rRNA is essential in yeast". J. Mol. Biol. 241: 492–497. doi:10.1006/jmbi.1994.1525. PMID 8064863.
↑ O'Farrell, H.C.; Pulicherla, N.; Desai, P.M.; Rife, J.P. (2006). "Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution". RNA. 12: 725–733. doi:10.1261/rna.2310406. PMID 16540698.

External links

18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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