16S rRNA (guanine527-N7)-methyltransferase

16S rRNA (guanine⁵²⁷-N⁷)-methyltransferase (EC 2.1.1.170, ribosomal RNA small subunit methyltransferase G, 16S rRNA methyltransferase RsmG, GidB, rsmG (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine⁵²⁷-N⁷)-methyltransferase.^[1]^[2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine⁵²⁷ in 16S rRNA

\rightleftharpoons

S-adenosyl-L-homocysteine + N7-methylguanine⁵²⁷ in 16S rRNA

The enzyme specifically methylates guanine⁵²⁷ at N⁷ in 16S rRNA.

References

↑ Okamoto, S.; Tamaru, A.; Nakajima, C.; Nishimura, K.; Tanaka, Y.; Tokuyama, S.; Suzuki, Y.; Ochi, K. (2007). "Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria". Mol. Microbiol. 63: 1096–1106. doi:10.1111/j.1365-2958.2006.05585.x. PMID 17238915.
↑ Romanowski, M.J.; Bonanno, J.B.; Burley, S.K. (2002). "Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold". Proteins. 47: 563–567. doi:10.1002/prot.10121. PMID 12001236.

External links

16S rRNA (guanine527-N7)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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